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            <div class="dt f36 font-m">Paracetamol (Oral)</div>
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              <div class="bt f24 font-m">Physico-Chemical Properties</div>
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              <div class="bt f24 font-m">Pharmacodynamics</div>
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                Animal and clinical studies have determined that acetaminophen
                has both antipyretic and analgesic effects. <br />
                This drug has been shown to lack anti-inflammatory effects.As
                opposed to the salicylate drug class,acetaminophen does not
                disrupt tubular secretion of uric acid and does not affect
                acid-base balance if taken at the recommended doses.23
                Acetaminophen does not disrupt hemostasis and does not have
                inhibitory activities against platelet aggregation.Label,23
                Allergic reactions are rare occurrences following acetaminophen
                use.23
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              <div class="bt f24 font-m">Mechanism of action</div>
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                According to its FDA labeling,acetaminophen's exact mechanism of
                action has not been fully establishedLabel despite this,it is
                often categorized alongside NSAlDs (nonsteroidal
                anti-inflammatory drugs)due to its ability to inhibit the
                cyclooxygenase (COX)pathways.14 It is thought to exert central
                actions which ultimately lead to the alleviation of pain
                symptoms.14One theory is that acetaminophen increases the pain
                threshold by inhibiting two isoforms of cyclooxygenase,COX-1 and
                COX-2,which are involved in prostaglandin
                (PG)synthesis.Prostaglandins are responsible for eliciting pain
                sensations.13 Acetaminophen does not inhibit cyclooxygenase in
                peripheral tissues and,therefore,has no peripheral
                anti-inflammatory effects.Though acetylsalicylic acid
                (aspirin)is an irreversible inhibitor of COX and directly blocks
                the active site of this enzyme,studies have shown that
                acetaminophen (paracetamol)blocks COX indirectly.24 Studies also
                suggest that acetaminophen selectively blocks a variant type of
                the COX enzyme that is unique from the known variants COX-1 and
                COX-2.6 This enzyme has been referred to as COX-3.The
                antipyretic actions of acetaminophen are likely attributed to
                direct action on heat-regulating centers in the brain,resulting
                in peripheral vasodilation,sweating,and loss of body heat.24 The
                exact mechanism of action of this drug is not fully understood
                at this time. but future research may contribute to deeper
                knowledge.24
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              <div class="bt f24 font-m">Indication</div>
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                In general,acetaminophen is used for the treatment of mild to
                moderate pain and reduction of fever.23 It is available over the
                counter in various forms,the most common being oral forms.
                Acetaminophen injection is indicated for the management of mild
                to moderate pain,the management of moderate to severe pain with
                adjunctive opioid analgesics,and the reduction of fever. Label
                Because of its low risk of causing allergic reactions,this drug
                can be administered in patients who are intolerant to
                salicylates and those with allergic tendencies,including
                bronchial asthmatics.23 Specific dosing guidelines should be
                followed when administering acetaminophen to children.18
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              <div class="bt f24 font-m">Objective and Search Strategy</div>
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                At present,pharmaceutical companies are investing significant
                effort to assess and control crosscontamination risk of drug
                products that are manufactured in the shared production
                facilities(2). Determination of health-based exposure limits for
                a residual active substance through the derivation of a safe
                threshold value is employed to identify the risk posed.The
                derivation of threshold value like permitted daily
                exposure(PDE)or threshold of toxicological concern is used to
                determine the risk of the active pharmaceutical substance.For
                determination of PDE all the available pharmacological and
                toxicological data including both non-clinical and clinical data
                should be evaluated.This involves hazard identification by
                reviewing all relevant data, identification of critical
                effects,determination of NOAEL of the findings that are
                considered to be critical effects. In this document,a summary of
                pharmacological,pharmacokinetics and toxicity data of
                paracetamol has been presented based on the published data.The
                data were extracted from Pub chem,Drug bank and FDA.
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                <div class="tl f24 font-m">Hazard Identified</div>
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                  <div class="ll">Carcinogen</div>
                  <div class="lc">NO</div>
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                    Carcinogenic studies conducted in mice and rats did not
                    revealed any carcinogenic potential of paracetamol
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                  <div class="ll">Genotoxicant</div>
                  <div class="lc">NO</div>
                  <div class="lr">
                    Paracetamol doesn't produce mutagenicity in Ames test
                    conducted in S.typhimurium strains but it produced sister
                    chromatid exchanges and chromosomal aberrations in Chinese
                    Hamster ovary cells,however it is highly unlikely that
                    paracetamol can produce mutagenic effects in humans.
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                  <div class="ll">Reproductive/Developmental Toxicant</div>
                  <div class="lc">NO</div>
                  <div class="lr">
                    Reproductive studies were conducted in rats and
                    rabbits.Testicular atrophy,fertility impairment and
                    fetotoxicity was observed in rats at higher doses and
                    reductions in fertility and neonatal survival, sperm
                    abnormalities were observed in mice.
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                  <div class="ll">Highly Sensitizing Potential</div>
                  <div class="lc">UNKNOWN</div>
                  <div class="lr">
                    There weren't any positive indicators in local tolerance
                    study conducted in rabbits and in skin sensitization study
                    performed in guinea pigs.
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                  Critical Effects <br />
                  hepatotoxicity and nephrotoxicity
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                  <NuxtLink to="/Apis/PDE">More Details</NuxtLink>
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                  <div class="ll">Non-clinical</div>
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                    The critical or lead effects of paracetamol were reported to
                    be hepatotoxicity and nephrotoxicity[<a href="">1</a>].
                  </div>
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                  <div class="ll">Clinical</div>
                  <div class="lr">
                    Paracetamol is used in the management of mild to moderate
                    pain and reduction of fever.It is also used in the
                    management of moderate to severe pain with adjunctive opioid
                    analgesics.The most common adverse effects associated with
                    paracetamol wereincreased aspartate
                    aminotransferase,nausea,vomiting,abdominal
                    pain,diarrhea,constipation,dyspepsia,enlarged
                    abdomen,insomnia,rash,pruritus,insomnia,anxiety,fatigue.Administration
                    of acetaminophen in doses higher than recommended may result
                    in hepatic injury.
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                  Point of Departure<br />
                  400 mg/kg/day
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                    Repeated dose toxicity studies were conducted in rodents up
                    to 13 weeks.From the availabledata,value of 400 mg/kg/day is
                    selected as NOAEL for the derivation of final PDE value from
                    rat's4-week. The rationale behind selection of this study as
                    it was conducted by intravenous route and the
                    oralbioavailability is 88%and is approximately equal to
                    intravenous route.Moreover,all doses welltolerated and no
                    histological liver changes or changes in liver enzymes or
                    bilirubin,and there areno indications of renal damage.
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                <div class="tl f24 font-m">Uncertainty Factors</div>
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                <table>
                  <tbody>
                    <tr>
                      <th class="f18 font-m">Factors</th>
                      <th class="f18 font-m">Value</th>
                      <th class="f18 font-m">Rationale</th>
                    </tr>
                    <tr>
                      <td class="f18 font-m">F1</td>
                      <td class="f18 font-m">5</td>
                      <td>For extrapolation from rats to humans.</td>
                    </tr>
                    <tr>
                      <td class="f18 font-m">F2</td>
                      <td class="f18 font-m">10</td>
                      <td>
                        Conventionally used to allow for differences between
                        individuals in the human population.
                      </td>
                    </tr>
                    <tr>
                      <td class="f18 font-m">F3</td>
                      <td class="f18 font-m">10</td>
                      <td>For selection of 4-week toxicity study in rats.</td>
                    </tr>
                    <tr>
                      <td class="f18 font-m">F4</td>
                      <td class="f18 font-m">5</td>
                      <td>Based on the hepatotoxicity.</td>
                    </tr>
                    <tr>
                      <td class="f18 font-m">F5</td>
                      <td class="f18 font-m">1</td>
                      <td>Selection of LOAEL dose.</td>
                    </tr>
                    <tr>
                      <td class="f18 font-m">α</td>
                      <td class="f18 font-m">1</td>
                      <td>A factor of 1 is applied.</td>
                    </tr>
                  </tbody>
                </table>
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                <div class="tl f24 font-m">PDE Calculation</div>
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              <div class="bt f24 font-m">References</div>
              <div class="btxt f16">
                <ul>
                  <li>
                    Forrest JA,Clements JA,Prescott LF:Clinical pharmacokinetics
                    of paracetamol.Clin Pharmacokinet.1982
                    Mar-Apr;7(2):93-107.[<a href="">Article</a>]
                  </li>
                  <li>
                    Ricciotti E,FitzGerald GA:Prostaglandins and
                    inflammation.Arterioscler Thromb Vasc Biol.
                    2011May;31(5):986-1000.doi: 10.1161/ATVBAHA.110. 207449.[<a
                      href=""
                      >Article</a
                    >]
                  </li>
                  <li>
                    Valerie Gerriets;Thomas M.Nappe
                    (2019).Acetaminophen.StatPearls publishing.
                  </li>
                  <li>Acetaminophen tablet,DailyMed [<a href="">Link</a>]</li>
                  <li>
                    Acetaminophen effervescent tablets,Cleveland Clinic [<a
                      href=""
                      >Link</a
                    >]
                  </li>
                  <li>
                    FDA safety communication:FDA has reviewed possible risks of
                    pain medicine use during pregnancy [<a href="">Link</a>]
                  </li>
                  <li>
                    U.S.National Medical Library:MedlinePlus-Acetaminophen
                    dosing for children [<a href="">Link</a>]
                  </li>
                  <li>
                    FDA consumer health information:Acetaminophen [<a href=""
                      >Link</a
                    >]
                  </li>
                  <li>FDA Acetaminophen Information [<a href="">Link</a>]</li>
                  <li>
                    Using Acetaminophen and Nonsteroidal Anti-inflammatory Drugs
                    Safely [<a href="">Link</a>]
                  </li>
                  <li>
                    FDA Approved Drug Products:Acetaminophen solution for
                    intravenous injection [<a href="">Link</a>]
                  </li>
                  <li>
                    Acetaminophen monograph,suppository [<a href="">File</a>]
                  </li>
                </ul>
              </div>
            </div>
          </div>
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      </div>
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                    <div class="dt f36 font-m">Non-clinical Toxicity Data</div>
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                        <div class="bt f24 font-m">Acute toxicity studies</div>
                        <div class="btxt f16">
                            <table>
                                <tbody>
                                    <tr>
                                        <th class="f18 font-m">Species</th>
                                        <th class="f18 font-m">Route</th>
                                        <th class="f18 font-m">LD50 value (mg/kg)</th>
                                    </tr>
                                    <tr>
                                        <td>Mice</td>
                                        <td>Oral</td>
                                        <td>338</td>
                                    </tr>
                                    <tr>
                                        <td>Mice</td>
                                        <td>Intraperitoneal</td>
                                        <td>367</td>
                                    </tr>
                                    <tr>
                                        <td>Mice</td>
                                        <td>Subcutaneous</td>
                                        <td>310</td>
                                    </tr>
                                    <tr>
                                        <td>Rats</td>
                                        <td>Oral</td>
                                        <td>1944</td>
                                    </tr>
                                </tbody>
                            </table>
                        </div>
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                        <div class="bt f24 font-m">Repeated dose toxicity studies</div>
                        <div class="btxt f16">
                            <table>
                                <tbody>
                                    <tr>
                                        <th class="f18 font-m">Species</th>
                                        <th class="f18 font-m">Route</th>
                                        <th class="f18 font-m">Doses </th>
                                        <th class="f18 font-m">Duratioin </th>
                                        <th class="f18 font-m">Key Findings</th>
                                    </tr>
                                    <tr>
                                        <td>Mice</td>
                                        <td>Oral (diet) </td>
                                        <td>50, 500, 1000, 2000 or 4000ppm in food corresponding to 60, 125, 250, 500,
                                            1000mg/kg/day</td>
                                        <td>2 weeks</td>
                                        <td>i. Well tolerated up to the highest dose. NOAEL 1000 mg/kg/day
                                            (4000Ppm)</td>
                                    </tr>
                                    <tr>
                                        <td>Mice</td>
                                        <td>Oral (diet) </td>
                                        <td>800, 1600, 3200, 6200, 12500 or 25000 ppm in food correspondin gt0200, 400,
                                            800, 1600, 3200 and
                                            6400 mg/kg/day</td>
                                        <td>13 weeks</td>
                                        <td>i.Hepatotoxicity,organ weight ch
                                            anges and deaths were observed
                                            at high doses.ii.Drug-related lesi
                                            ons in mice were found in the liv
                                            er (hepatocytomegaly,focal calci
                                            fication,pigmentation,necrosis)
                                            of males that received 6,200,12,
                                            500,or 25000 ppm and females that received 12,000 or 25000 ppm NOAEL=400
                                            mg/kg/day(males)
                                            and 800 mg/kg/day (females)(1
                                            600 and 3200 ppm)
                                        </td>
                                    </tr>
                                    <tr>
                                        <td>Rats</td>
                                        <td>Oral (diet) </td>
                                        <td>800, 1600, 3100, 6200 or 12500 ppm in food corresponding to 100, 200, 400,
                                            800, 1600mg/Kg/day</td>
                                        <td>2 weeks</td>
                                        <td>i.Reduced body weight in males at the highest dose.
                                            NOAEL-400 mg/kg/day</td>
                                    </tr>
                                </tbody>
                            </table>
                        </div>
                    </div>
                    <div class="dblock">
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                        <div class="bt f24 font-m">Carcinogenicity studies</div>
                        <div class="btxt f16">
                            <table>
                                <tbody>
                                    <tr>
                                        <th class="f18 font-m">Species</th>
                                        <th class="f18 font-m">Route</th>
                                        <th class="f18 font-m">Doses </th>
                                        <th class="f18 font-m">Duratioin </th>
                                        <th class="f18 font-m">Key Findings</th>
                                    </tr>
                                    <tr>
                                        <td>Mice</td>
                                        <td>Oral (diet) </td>
                                        <td>50, 500, 1000, 2000 or 4000ppm in food corresponding to 60, 125, 250, 500,
                                            1000mg/kg/day</td>
                                        <td>2 weeks</td>
                                        <td>i. Well tolerated up to the highest dose. NOAEL 1000 mg/kg/day
                                            (4000Ppm)</td>
                                    </tr>
                                    <tr>
                                        <td>Mice</td>
                                        <td>Oral (diet) </td>
                                        <td>800, 1600, 3200, 6200, 12500 or 25000 ppm in food correspondin gt0200, 400,
                                            800, 1600, 3200 and
                                            6400 mg/kg/day</td>
                                        <td>13 weeks</td>
                                        <td>i.Hepatotoxicity,organ weight ch
                                            anges and deaths were observed
                                            at high doses.ii.Drug-related lesi
                                            ons in mice were found in the liv
                                            er (hepatocytomegaly,focal calci
                                            fication,pigmentation,necrosis)
                                            of males that received 6,200,12,
                                            500,or 25000 ppm and females that received 12,000 or 25000 ppm NOAEL=400
                                            mg/kg/day(males)
                                            and 800 mg/kg/day (females)(1
                                            600 and 3200 ppm)
                                        </td>
                                    </tr>
                                    <tr>
                                        <td>Rats</td>
                                        <td>Oral (diet) </td>
                                        <td>800, 1600, 3100, 6200 or 12500 ppm in food corresponding to 100, 200, 400,
                                            800, 1600mg/Kg/day</td>
                                        <td>2 weeks</td>
                                        <td>i.Reduced body weight in males at the highest dose.
                                            NOAEL-400 mg/kg/day</td>
                                    </tr>
                                </tbody>
                            </table>
                        </div>
                    </div>
                    <div class="dblock">
                        <div id="p4" class="pos"></div>
                        <div class="bt f24 font-m">In-vivo/In-vitro genotoxicity studies</div>
                        <div class="btxt f16">
                            <table>
                                <tbody>
                                    <tr>
                                        <th class="f18 font-m">Test/Assay </th>
                                        <th class="f18 font-m">Cell lines/Organism </th>
                                        <th class="f18 font-m">Concentration/Dose </th>
                                        <th class="f18 font-m">Findings </th>
                                        <th class="f18 font-m">Note </th>
                                    </tr>
                                    <tr>
                                        <td>Bacterial mutation
                                            test (In-vitro)</td>
                                        <td>Salmonella typhimurium:(TA
                                            1535,TA1537,TA98,TA100)
                                            E.coli WP2 trp uvrA</td>
                                        <td>1.58,5,15.8,50,158,500,158
                                            1,5000μg/plate</td>
                                        <td>Negative</td>
                                        <td></td>
                                    </tr>
                                    <tr>
                                        <td>Chromosomal aberration test</td>
                                        <td>CHO cell</td>
                                        <td>Upto5000μg/mL</td>
                                        <td>Colchicine without metabolic activation was positive for Chromosomal
                                            aberration test</td>
                                        <td></td>
                                    </tr>
                                </tbody>
                            </table>
                        </div>
                    </div>
                    <div class="dblock">
                        <div id="p5" class="pos"></div>
                        <div class="bt f24 font-m">Reproductive and developmental studies</div>
                        <div class="btxt f16">
                            <table>
                                <tbody>
                                    <tr>
                                        <th class="f18 font-m">Species</th>
                                        <th class="f18 font-m">Route </th>
                                        <th class="f18 font-m">Doses(mg/kg/day) </th>
                                        <th class="f18 font-m">Duratioin </th>
                                        <th class="f18 font-m">Key Findings </th>
                                    </tr>
                                    <tr>
                                        <td class="f18 font-m" colspan="5"
                                            style="background: #f5f5f5;text-align: center;color: #242424;padding: 10px;">
                                            Reproductive/continuous breeding study
                                        </td>
                                    </tr>
                                    <tr>
                                        <td>Mice </td>
                                        <td>Oral (diet) </td>
                                        <td>360, 720, 1400 (0.25, 0.5, 1% infeed)</td>
                                        <td>Continuous breeding
                                            phaseconsists of a 7day
                                            premating exposure,a 98 day cohabitation period, and a 21 day segregation
                                            period</td>
                                        <td>i.Minor reductions in fertility and
                                            neonatal survival were seen in the F0
                                            generation decreases in F1 pup weights at 1400 mg/kg.Sperm abnormalities
                                            were reported at the highest dose,but not investigated in the lower dose
                                            groups.
                                            ii.Overall NOAEL is not established
                                            NOAEL-720 mg/kg/day for
                                            embryotoxicity</td>
                                    </tr>
                                    <tr>
                                        <td class="f18 font-m" colspan="5"
                                            style="background: #f5f5f5;text-align: center;color: #242424;padding: 10px;">
                                            Male reproductive function study
                                        </td>
                                    </tr>
                                    <tr>
                                        <td>Rats </td>
                                        <td>Oral </td>
                                        <td>500, 700, 1100, 1400, 2500, 3000, 4000</td>
                                        <td>100 days</td>
                                        <td>i.Testicular atrophy (the testicular weight decreased by around 40%) and
                                            fertility impairment (reduced
                                            spermatozoa motility and counts, lower pregnancy rate and higher
                                            pre-implantation loss in females mated with treated male).
                                            LOAEL=500 mg/kg/day
                                        </td>
                                    </tr>
                                    <tr>
                                        <td class="f18 font-m" colspan="5"
                                            style="background: #f5f5f5;text-align: center;color: #242424;padding: 10px;">
                                            Embryotoxicity study
                                        </td>
                                    </tr>
                                    <tr>
                                        <td>Rats </td>
                                        <td>Oral </td>
                                        <td>125, 250, 500</td>
                                        <td>Period of organogenesis is covered</td>
                                        <td>i.Resorptions were seen only at 125
                                            mg/kg accompanied by a significant
                                            decrease in fetal length.The authors
                                            concluded that rat embryos are sensitive to metabolic perturbation caused by
                                            maternal exposure to paracetamol.This study does not appear to examine
                                            visceral or skeletal malformations.
                                            LOAEL=125 mg/kg/day
                                        </td>
                                    </tr>
                                    <tr>
                                        <td class="f18 font-m" colspan="5"
                                            style="background: #f5f5f5;text-align: center;color: #242424;padding: 10px;">
                                            Embryotoxicity study (effects on maternal and fetal liver and kidney were
                                            investigated)
                                        </td>
                                    </tr>
                                    <tr>
                                        <td>Rats </td>
                                        <td>Oral </td>
                                        <td>125, 250, 500</td>
                                        <td>Period of organogenesis is covered</td>
                                        <td>i.At 500 mg/kg necrotic areas in
                                            kidney and liver in both maternal and
                                            fetal tissues.
                                            NOAEL=125 mg/kg/day
                                        </td>
                                    </tr>
                                </tbody>
                            </table>
                            <br>
                            <p> <b>*Pregnancy category C:</b> There are no adequate and well controlled studies in
                                pregnant women.however,epidemiological data on oral acetaminophen use in pregnant women
                                show no increased risk of major congenital malformations (7).
                            </p>
                        </div>
                    </div>
                    <div class="dblock">
                        <div id="p6" class="pos"></div>
                        <div class="bt f24 font-m">Highly sensitizing potential </div>
                        <div class="btxt f16">
                            <b>Local tolerance study in rabbits-</b>There were no relevant treatment related changes at
                            the injection site when acetaminophen was
                            administered via the intravenous and perivenous routes.Slight increases in perivascular
                            haemorrhage and perivascular acute
                            inflammation were observed in animals administered acetaminophen via the intra-arterial
                            route(<a href="">5</a>). <br>
                            <b>Skin Sensitization Test in Guinea-Pigs-</b>Acetaminophen did not induce delayed contact
                            hypersensitivity in guinea-pigs when
                            administered either via the intradermal or cutaneous routes of administration( <a
                                href="">5</a> ).

                        </div>
                    </div>
                </div>
            </div>
        </div>
        <div class="detailBox gray">
            <div class="box flex page-inner">
                <div class="cor">
                    <div class="dt f36 font-m">Clinical Toxicity Data</div>
                    <div class="dblock">
                        <div id="p7" class="pos"></div>
                        <div class="bt f24 font-m">Pharmacodynamics data</div>
                        <div class="btxt f16">
                            Acetaminophen increases the pain threshold by inhibiting two isoforms of
                            cyclooxygenase,COX-1 and COX-2,which are involved in
                            prostaglandin(PG)synthesis.Prostaglandins are responsible for eliciting pain sensations.As
                            opposed to the salicylate drug class,
                            acetaminophen does not disrupt tubular secretion of uric acid and does not affect acid-base
                            balance if taken at the recommended doses( <a href="">3</a> )

                        </div>
                    </div>
                    <div class="dblock">
                        <div id="p8" class="pos"></div>
                        <div class="bt f24 font-m">Carcinogenicity </div>
                        <div class="btxt f16">
                            No component of this product present at levels greater than or equal to 0.1%is identified as
                            probable,possible,or confirmed human carcinogen by IARC(International Agency for Research on
                            Cancer)( <a href="">6</a> )


                        </div>
                    </div>
                    <div class="dblock">
                        <div id="p9" class="pos"></div>
                        <div class="bt f24 font-m">Reproductive and developmental studies </div>
                        <div class="btxt f16">

                            *Pregnancy category C:There are no adequate and well controlled studies in pregnant
                            women.however,epidemiological data on oral
                            acetaminophen use in pregnant women show no increased risk of major congenital
                            malformations( <a href="">7</a> ).

                        </div>
                    </div>
                    <div class="dblock">
                        <div id="p10" class="pos"></div>
                        <div class="bt f24 font-m">Highly sensitizing potential </div>
                        <div class="btxt f16">
                            No relevant clinical data regarding the sensitization potential was available in literature

                        </div>
                    </div>
                </div>
            </div>
        </div>
    </div>
    <div>
        <div class="detailBox" id="p1">
            <div class="box flex page-inner">
                <div class="cor">
                    <div class="dt f36 font-m">Study-specified  PDE</div>
                    <div class="dt2 f24 font-m">Calculated PDE based on Clinical Data</div>
                    <div class="PDEList f16">
                        <el-table :data="list" style="width: 100%">
                            <el-table-column prop="StudylD" label="StudylD">
                                <template #default="scope">
                                    <div class="vm" @click="showDetail(scope.row)">
                                        <span>{{ scope.row.StudylD }}</span>
                                        <span class="ico">+</span>
                                    </div>
                                </template>
                            </el-table-column>
                            <el-table-column prop="Country" label="Country">
                                <template #default="scope">{{ scope.row.Country }}</template>
                            </el-table-column>
                            <el-table-column prop="CriticalEffect" label="Critical Effect">
                                <template #default="scope">{{ scope.row.CriticalEffect }}</template>
                            </el-table-column>
                            <el-table-column prop="Routes" label="Routes">
                                <template #default="scope"><span class="blue">{{ scope.row.Routes }}</span></template>
                            </el-table-column>
                            <el-table-column prop="Species" label="Species">
                                <template #default="scope">{{ scope.row.Species }}</template>
                            </el-table-column>
                            <el-table-column prop="PoD" label="PoD (mg/kg/day) ">
                                <template #default="scope">{{ scope.row.PoD }}</template>
                            </el-table-column>
                            <el-table-column prop="PDE" label="PDE (mg/day) ">
                                <template #default="scope">{{ scope.row.PDE }}</template>
                            </el-table-column>
                        </el-table>
                    </div>
                </div>
            </div>
        </div>
        <div class="detailBox">
            <div class="page-inner">
                <div class="poptable ">
            <div v-html="list[0]?.Details"></div>
        </div>
            </div>
        </div>
    </div>
  </div>
</template>
<script>
import { apiInfo } from "@/api/sections";
import { ElMessageBox } from "element-plus";
export default {
  async setup() {
    const route = useRoute();
    const contentRef = ref(null);
    const info = {
      name: "Paracetamol (Oral)",
      IUPACName: "",
    };
    const state = useState("global_userInfo");

    return { info, state };
  },
  data() {
    return {
      dataInfo: {},
      list:[]
    };
  },
  methods: {
    hasPermision: function (id) {
      const that = this;
      return that.state.permission.includes(id) || false;
    },
    getList(){
            const that=this;
            let res={
                Data:[
                    {
                        StudylD:1,
                        Country:"US",
                        CriticalEffect:"Reduction of fever",
                        Routes:"V infusion",
                        Species:"adult",
                        PoD:"80",
                        PDE:"4",
                        Details:`<table> <tbody> <tr> <th class="f18 font-m">Factors</th> <th class="f18 font-m">Value</th> <th class="f18 font-m">Rationale</th> </tr> <tr> <td>PoD</td> <td>125</td> <td>mg/kg/day,oral,select no adverse effect dose(NOAEL)</td> </tr> <tr> <td>Weight Adjustment</td> <td>20</td> <td>default value (adult)</td> </tr> <tr> <td>F1:Extrapolation between species</td> <td>6.2</td> <td>rat to human</td> </tr> <tr> <td>F2:Interindividual variability</td> <td>10</td> <td>default value</td> </tr> <tr> <td>F3:Duration of exposure</td> <td>1</td> <td>continuous breeding</td> </tr> <tr> <td>F4:Nature of toxicity</td> <td>5</td> <td>foetal toxicity with maternal toxicity</td> </tr> <tr> <td>F5:NO(A)EL/LO(A)EL</td> <td>1</td> <td>NOAEL</td> </tr> <tr> <td>a</td> <td>1</td> <td>A factor of 1 is applied.</td> </tr> <tr> <td>Derived PDE(mg/day)</td> <td colspan="2">20.16129032</td> </tr> <tr> <td>Derived PDE (μg/day)</td> <td colspan="2">20161.29032</td> </tr> </tbody> </table>`
                    },
                    {
                        StudylD:2,
                        Country:"US",
                        CriticalEffect:"Reduction of fever",
                        Routes:"V infusion",
                        Species:"neonates",
                        PoD:"80",
                        PDE:"4",
                        Details:`<table> <tbody> <tr> <th class="f18 font-m">Factors</th> <th class="f18 font-m">Value</th> <th class="f18 font-m">Rationale</th> </tr> <tr> <td>PoD</td> <td>125</td> <td>mg/kg/day,oral,select no adverse effect dose(NOAEL)</td> </tr> <tr> <td>Weight Adjustment</td> <td>20</td> <td>default value (adult)</td> </tr> <tr> <td>F1:Extrapolation between species</td> <td>6.2</td> <td>rat to human</td> </tr> <tr> <td>F2:Interindividual variability</td> <td>10</td> <td>default value</td> </tr> <tr> <td>F3:Duration of exposure</td> <td>1</td> <td>continuous breeding</td> </tr> <tr> <td>F4:Nature of toxicity</td> <td>5</td> <td>foetal toxicity with maternal toxicity</td> </tr> <tr> <td>F5:NO(A)EL/LO(A)EL</td> <td>1</td> <td>NOAEL</td> </tr> <tr> <td>a</td> <td>1</td> <td>A factor of 1 is applied.</td> </tr> <tr> <td>Derived PDE(mg/day)</td> <td colspan="2">20.16129032</td> </tr> <tr> <td>Derived PDE (μg/day)</td> <td colspan="2">20161.29032</td> </tr> </tbody> </table>`
                    },
                    {
                        StudylD:3,
                        Country:"CN",
                        CriticalEffect:"Reduction of fever",
                        Routes:"Oral",
                        Species:"adult",
                        PoD:"80",
                        PDE:"4",
                        Details:`<table> <tbody> <tr> <th class="f18 font-m">Factors</th> <th class="f18 font-m">Value</th> <th class="f18 font-m">Rationale</th> </tr> <tr> <td>PoD</td> <td>125</td> <td>mg/kg/day,oral,select no adverse effect dose(NOAEL)</td> </tr> <tr> <td>Weight Adjustment</td> <td>20</td> <td>default value (adult)</td> </tr> <tr> <td>F1:Extrapolation between species</td> <td>6.2</td> <td>rat to human</td> </tr> <tr> <td>F2:Interindividual variability</td> <td>10</td> <td>default value</td> </tr> <tr> <td>F3:Duration of exposure</td> <td>1</td> <td>continuous breeding</td> </tr> <tr> <td>F4:Nature of toxicity</td> <td>5</td> <td>foetal toxicity with maternal toxicity</td> </tr> <tr> <td>F5:NO(A)EL/LO(A)EL</td> <td>1</td> <td>NOAEL</td> </tr> <tr> <td>a</td> <td>1</td> <td>A factor of 1 is applied.</td> </tr> <tr> <td>Derived PDE(mg/day)</td> <td colspan="2">20.16129032</td> </tr> <tr> <td>Derived PDE (μg/day)</td> <td colspan="2">20161.29032</td> </tr> </tbody> </table>`
                    },
                    {
                        StudylD:4,
                        Country:"CN",
                        CriticalEffect:"Reduction of fever",
                        Routes:"Oral",
                        Species:"pediatric",
                        PoD:"80",
                        PDE:"4",
                        Details:`<table> <tbody> <tr> <th class="f18 font-m">Factors</th> <th class="f18 font-m">Value</th> <th class="f18 font-m">Rationale</th> </tr> <tr> <td>PoD</td> <td>125</td> <td>mg/kg/day,oral,select no adverse effect dose(NOAEL)</td> </tr> <tr> <td>Weight Adjustment</td> <td>20</td> <td>default value (adult)</td> </tr> <tr> <td>F1:Extrapolation between species</td> <td>6.2</td> <td>rat to human</td> </tr> <tr> <td>F2:Interindividual variability</td> <td>10</td> <td>default value</td> </tr> <tr> <td>F3:Duration of exposure</td> <td>1</td> <td>continuous breeding</td> </tr> <tr> <td>F4:Nature of toxicity</td> <td>5</td> <td>foetal toxicity with maternal toxicity</td> </tr> <tr> <td>F5:NO(A)EL/LO(A)EL</td> <td>1</td> <td>NOAEL</td> </tr> <tr> <td>a</td> <td>1</td> <td>A factor of 1 is applied.</td> </tr> <tr> <td>Derived PDE(mg/day)</td> <td colspan="2">20.16129032</td> </tr> <tr> <td>Derived PDE (μg/day)</td> <td colspan="2">20161.29032</td> </tr> </tbody> </table>`
                    },
                    {
                        StudylD:5,
                        Country:"CN",
                        CriticalEffect:"Reduction of fever",
                        Routes:"IM",
                        Species:"adult",
                        PoD:"80",
                        PDE:"4",
                        Details:`<table> <tbody> <tr> <th class="f18 font-m">Factors</th> <th class="f18 font-m">Value</th> <th class="f18 font-m">Rationale</th> </tr> <tr> <td>PoD</td> <td>125</td> <td>mg/kg/day,oral,select no adverse effect dose(NOAEL)</td> </tr> <tr> <td>Weight Adjustment</td> <td>20</td> <td>default value (adult)</td> </tr> <tr> <td>F1:Extrapolation between species</td> <td>6.2</td> <td>rat to human</td> </tr> <tr> <td>F2:Interindividual variability</td> <td>10</td> <td>default value</td> </tr> <tr> <td>F3:Duration of exposure</td> <td>1</td> <td>continuous breeding</td> </tr> <tr> <td>F4:Nature of toxicity</td> <td>5</td> <td>foetal toxicity with maternal toxicity</td> </tr> <tr> <td>F5:NO(A)EL/LO(A)EL</td> <td>1</td> <td>NOAEL</td> </tr> <tr> <td>a</td> <td>1</td> <td>A factor of 1 is applied.</td> </tr> <tr> <td>Derived PDE(mg/day)</td> <td colspan="2">20.16129032</td> </tr> <tr> <td>Derived PDE (μg/day)</td> <td colspan="2">20161.29032</td> </tr> </tbody> </table>`
                    },
                    {
                        StudylD:6,
                        Country:"CN",
                        CriticalEffect:"Reduction of fever",
                        Routes:"IM",
                        Species:"pediatric",
                        PoD:"80",
                        PDE:"4",
                        Details:`<table> <tbody> <tr> <th class="f18 font-m">Factors</th> <th class="f18 font-m">Value</th> <th class="f18 font-m">Rationale</th> </tr> <tr> <td>PoD</td> <td>125</td> <td>mg/kg/day,oral,select no adverse effect dose(NOAEL)</td> </tr> <tr> <td>Weight Adjustment</td> <td>20</td> <td>default value (adult)</td> </tr> <tr> <td>F1:Extrapolation between species</td> <td>6.2</td> <td>rat to human</td> </tr> <tr> <td>F2:Interindividual variability</td> <td>10</td> <td>default value</td> </tr> <tr> <td>F3:Duration of exposure</td> <td>1</td> <td>continuous breeding</td> </tr> <tr> <td>F4:Nature of toxicity</td> <td>5</td> <td>foetal toxicity with maternal toxicity</td> </tr> <tr> <td>F5:NO(A)EL/LO(A)EL</td> <td>1</td> <td>NOAEL</td> </tr> <tr> <td>a</td> <td>1</td> <td>A factor of 1 is applied.</td> </tr> <tr> <td>Derived PDE(mg/day)</td> <td colspan="2">20.16129032</td> </tr> <tr> <td>Derived PDE (μg/day)</td> <td colspan="2">20161.29032</td> </tr> </tbody> </table>`
                    },
                    {
                        StudylD:7,
                        Country:"US",
                        CriticalEffect:"Reduction of fever",
                        Routes:"V infusion",
                        Species:"adult",
                        PoD:"80",
                        PDE:"4",
                        Details:`<table> <tbody> <tr> <th class="f18 font-m">Factors</th> <th class="f18 font-m">Value</th> <th class="f18 font-m">Rationale</th> </tr> <tr> <td>PoD</td> <td>125</td> <td>mg/kg/day,oral,select no adverse effect dose(NOAEL)</td> </tr> <tr> <td>Weight Adjustment</td> <td>20</td> <td>default value (adult)</td> </tr> <tr> <td>F1:Extrapolation between species</td> <td>6.2</td> <td>rat to human</td> </tr> <tr> <td>F2:Interindividual variability</td> <td>10</td> <td>default value</td> </tr> <tr> <td>F3:Duration of exposure</td> <td>1</td> <td>continuous breeding</td> </tr> <tr> <td>F4:Nature of toxicity</td> <td>5</td> <td>foetal toxicity with maternal toxicity</td> </tr> <tr> <td>F5:NO(A)EL/LO(A)EL</td> <td>1</td> <td>NOAEL</td> </tr> <tr> <td>a</td> <td>1</td> <td>A factor of 1 is applied.</td> </tr> <tr> <td>Derived PDE(mg/day)</td> <td colspan="2">20.16129032</td> </tr> <tr> <td>Derived PDE (μg/day)</td> <td colspan="2">20161.29032</td> </tr> </tbody> </table>`
                    },
                    {
                        StudylD:8,
                        Country:"CN",
                        CriticalEffect:"Reduction of fever",
                        Routes:"V infusion",
                        Species:"neonates",
                        PoD:"80",
                        PDE:"4",
                        Details:`<table> <tbody> <tr> <th class="f18 font-m">Factors</th> <th class="f18 font-m">Value</th> <th class="f18 font-m">Rationale</th> </tr> <tr> <td>PoD</td> <td>125</td> <td>mg/kg/day,oral,select no adverse effect dose(NOAEL)</td> </tr> <tr> <td>Weight Adjustment</td> <td>20</td> <td>default value (adult)</td> </tr> <tr> <td>F1:Extrapolation between species</td> <td>6.2</td> <td>rat to human</td> </tr> <tr> <td>F2:Interindividual variability</td> <td>10</td> <td>default value</td> </tr> <tr> <td>F3:Duration of exposure</td> <td>1</td> <td>continuous breeding</td> </tr> <tr> <td>F4:Nature of toxicity</td> <td>5</td> <td>foetal toxicity with maternal toxicity</td> </tr> <tr> <td>F5:NO(A)EL/LO(A)EL</td> <td>1</td> <td>NOAEL</td> </tr> <tr> <td>a</td> <td>1</td> <td>A factor of 1 is applied.</td> </tr> <tr> <td>Derived PDE(mg/day)</td> <td colspan="2">20.16129032</td> </tr> <tr> <td>Derived PDE (μg/day)</td> <td colspan="2">20161.29032</td> </tr> </tbody> </table>`
                    },
                    {
                        StudylD:9,
                        Country:"CN",
                        CriticalEffect:"Reduction of fever",
                        Routes:"Oral",
                        Species:"adult",
                        PoD:"80",
                        PDE:"4",
                        Details:`<table> <tbody> <tr> <th class="f18 font-m">Factors</th> <th class="f18 font-m">Value</th> <th class="f18 font-m">Rationale</th> </tr> <tr> <td>PoD</td> <td>125</td> <td>mg/kg/day,oral,select no adverse effect dose(NOAEL)</td> </tr> <tr> <td>Weight Adjustment</td> <td>20</td> <td>default value (adult)</td> </tr> <tr> <td>F1:Extrapolation between species</td> <td>6.2</td> <td>rat to human</td> </tr> <tr> <td>F2:Interindividual variability</td> <td>10</td> <td>default value</td> </tr> <tr> <td>F3:Duration of exposure</td> <td>1</td> <td>continuous breeding</td> </tr> <tr> <td>F4:Nature of toxicity</td> <td>5</td> <td>foetal toxicity with maternal toxicity</td> </tr> <tr> <td>F5:NO(A)EL/LO(A)EL</td> <td>1</td> <td>NOAEL</td> </tr> <tr> <td>a</td> <td>1</td> <td>A factor of 1 is applied.</td> </tr> <tr> <td>Derived PDE(mg/day)</td> <td colspan="2">20.16129032</td> </tr> <tr> <td>Derived PDE (μg/day)</td> <td colspan="2">20161.29032</td> </tr> </tbody> </table>`
                    },
                    {
                        StudylD:10,
                        Country:"CN",
                        CriticalEffect:"Reduction of fever",
                        Routes:"Oral",
                        Species:"pediatric",
                        PoD:"80",
                        PDE:"4",
                        Details:`<table> <tbody> <tr> <th class="f18 font-m">Factors</th> <th class="f18 font-m">Value</th> <th class="f18 font-m">Rationale</th> </tr> <tr> <td>PoD</td> <td>125</td> <td>mg/kg/day,oral,select no adverse effect dose(NOAEL)</td> </tr> <tr> <td>Weight Adjustment</td> <td>20</td> <td>default value (adult)</td> </tr> <tr> <td>F1:Extrapolation between species</td> <td>6.2</td> <td>rat to human</td> </tr> <tr> <td>F2:Interindividual variability</td> <td>10</td> <td>default value</td> </tr> <tr> <td>F3:Duration of exposure</td> <td>1</td> <td>continuous breeding</td> </tr> <tr> <td>F4:Nature of toxicity</td> <td>5</td> <td>foetal toxicity with maternal toxicity</td> </tr> <tr> <td>F5:NO(A)EL/LO(A)EL</td> <td>1</td> <td>NOAEL</td> </tr> <tr> <td>a</td> <td>1</td> <td>A factor of 1 is applied.</td> </tr> <tr> <td>Derived PDE(mg/day)</td> <td colspan="2">20.16129032</td> </tr> <tr> <td>Derived PDE (μg/day)</td> <td colspan="2">20161.29032</td> </tr> </tbody> </table>`
                    }
                ],
                Total:20
            };
            that.list=res.Data;
            that.total=res.Total;
        },
  },
  computed: {},
  mounted: function () {
    var that = this;
    that.$nextTick(function () {
      apiInfo({
        id: that.$route.query.id,
      }).then((res) => {
        this.dataInfo = res.data;
      });

      $(".toggleML").each(function () {
        var btn = $(this).find(".zk");
        var short = $(this).find(".span");
        var info = $(this).find(".hid");
        var line = $(this).find(".p");
        short.text(info.text().substr(0, 120) + "...");
        btn.click(function () {
          if ($(this).hasClass("act")) {
            $(this).removeClass("act");
            line.removeClass("act");
            short.text(info.text().substr(0, 120) + "...");
          } else {
            $(this).addClass("act");
            line.addClass("act");
            short.html(info.html());
          }
        });
      });
    });
    this.getList()
  },
};
</script>